Sue

Sorry to be the bearer of bad news, but I have just read this. I have put the bold font into the text. Although the research was with patients who had had organ transplants, it seems that the findings may also apply to people with auto-immune conditions: https://www.medpagetoday.com/infectiousdisease/vaccines/91631?xid=nl_mpt_DHE_2021-03-16&eun=g1781883d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Top%20Cat%20HeC%20%202021-03-16&utm_term=NL_Daily_DHE_dual-gmail-definition Taking care of a lot of immunosuppressed patients, one big question my Johns Hopkins colleagues and I have had throughout the pandemic has been: Will vaccines rescue them from the COVID-19 threat? Based on a new study we published today in JAMA, the answer appears to be: only for some. The day that the FDA granted the Pfizer COVID-19 vaccine an emergency use authorization, we launched a national study of vaccine immune responses in immunosuppressed solid organ transplant recipients. Among 436 COVID-na?ve participants who received a first dose of mRNA vaccine, only 17% mounted detectable antibodies to SARS-CoV-2. This is in stark contrast to immunocompetent people who were vaccinated, of whom 100% mounted detectable antibody; that was true for people who had received either the Pfizer-BioNTech or Moderna vaccine. We also found that those taking anti-metabolites, such as mycophenolate or azathioprine, were about five times less likely to develop antibody responses (8.75% detectable antibody in those taking anti-metabolites versus 41.4% in those not taking them). Naturally, we were disappointed to see these findings, as we were hoping to be able to tell our immunosuppressed patients that the vaccines seemed to work well for them. Given this observation, the CDC should update their new guidelines for vaccinated individuals to warn immunosuppressed people that they still may be susceptible to COVID-19 after vaccination. As the CDC guidelines are currently written, they assume that vaccination means immunity. Our study shows that this is unlikely for most transplant recipients, and one could guess that our findings (especially those concerning anti-metabolites) could also apply to other immunosuppressed patients, such as those with autoimmune conditions. Of note, our previous research has not found that immunosuppressed transplant patients are at increased risk of COVID-19 mortality as we thought might be the case. But regardless, the vaccine does not seem to work as well in this same population. As a transplant surgeon, there are a few implications for my patients. First, it seems pretty clear that immunosuppressed individuals need (at least) their second vaccine dose; proposals to stop at one dose until the rest of the population is vaccinated apply to immunocompetent people, but not to my patients. Second, it is critically important for immunosuppressed individuals to realize that they are not necessarily immune after receiving the vaccine, and to talk to their providers about antibody testing before relaxing protective behaviors. Fortunately, semiquantitative antibody tests like the ones used in our study are widely available, and correlate well with neutralizing immunity. Our study is ongoing, and soon we will have data from the second dose, as well as deeper studies of T-cell and B-cell responses, which can confer immunity even when antibodies are not present. We are also studying other vulnerable populations. Enrollment is open, we welcome new participants, and we hope to share more information soon. Dorry Segev, MD, PhD, is a professor of surgery and epidemiology and associate vice chair of surgery at Johns Hopkins University School of Medicine and Bloomberg School of Public Health.

malumbu Wrote: ------------------------------------------------------- > The pre-decimal > ha'penny dropped in 1970 would now be worth about > 8 pence. 8 pence? Not as much as that, surely? Anyway, never mind the ha'penny. I remember buying a ball of wool in Tyrells (sp?) in Streatham for sixpence three farthings 😂 It is very disconcerting when your childhood is history. If it had been Sharmans, a bit further up the road, my money would have gone whizzing up to the cashier on the floor above in one of those pneumatic tube things 😮

Done, thank you BNG

Are the cheeses in the vegan lasagne vegan? It isn't clear.

tiddles Wrote: ------------------------------------------------------- Made the mistake of googling > small tits..... not helpful... :)) :)) :))

https://www.theguardian.com/media/2021/mar/10/society-of-editors-steps-back-claim-racism-no-part-meghan-coverage?CMP=Share_AndroidApp_Other ETA: This now links to an article which has been updated since I posted the link.

Fantastic news! But according to a report I saw, ten children have gone missing in London in the last month alone.

ED - NAGAIUTB Wrote: ------------------------------------------------------- > DulwichDaddio Wrote: > -------------------------------------------------- > ----- > > Its a shame they then go ahead and charge so > much > > for the clothes they are given for free. Not > quite > > on the level of charity shops in say, Chelsea, > but > > still sadly overpriced. > > > Its how they make enough to support those with EOL > (look it up) conditions and their families. People > like my late partner. > > Remember the old maxim: If you can't say anything > nice, don't say anything at all. S/he was a troll. Now gone.

Administrator Wrote: ------------------------------------------------------- > Good spot Sidhue, DulwichDaddio is Stephen Taylor, > Trolley Snatcha etc Already spotted when DulwichDaddio first posted, and I thought reported .... Only a matter of time before the next incarnation, I suspect ....

I was called by the energy people this morning to check that everything was now ok. Apparently there was an explosion at the substation adjacent to 25 Lacon Road. Firefighters came very quickly and contained things, and there was no fire. Some people didn't get their power back till 3am, so Ulverscroft Road was relatively lucky! For future reference (let's hope not needed) the emergency number is 105.

https://www.theguardian.com/uk-news/2021/mar/10/sarah-everard-arrested-police-officer-not-on-duty-when-she-went-missing?CMP=Share_AndroidApp_Other This is truly awful. My thoughts with her family. Not knowing where she is or what may have happened to her must be unimaginably terrible.

ydrmdy Wrote: ------------------------------------------------------- > Probably a silly question has this been reported > to the police? OP said he or she had reported it to the police.

malumbu Wrote: -------------------------------------------------- On air quality you should really get a > Euro 6d If that's diesel, surely that's not good???

That has reminded me of being in primary school and doing pounds shillings and pence sums. What a stupid system. And as for all those weird things you used to get on the back of exercise books ..... I still remember totally useless things like 1760 yards in a mile ....

My partner was texted re an appointment to have his, he is mid fifties.

DulwichFox Wrote: ------------------------------------------------------- > Ulvercroft Rd Back on.. > > Foxy We've all been following it on the road WhatsApp group 🙂

I'll probably watch it at some point :)

malumbu Wrote: ------------------------------------------------------- > There's lots of 15 year old petrol > run-arounds on Autotrader that will be ULEZ exempt > for under a grand. But being ULEZ exempt does not depend on age. My car is 23 years old, but it won't pass the emissions test and to the best of my knowledge is not ULEZ exempt. You have to put in the actual registration number on the website to find out (which I did do. Sob.)

RichH Wrote: ------------------------------------------------------- > Bird bath etiquette is also fun to observe. When > one bird takes a bath it seems to trigger a frenzy > and suddenly they all want a go. Some species > appear happy bathing together like the Blue Tit, > multiple Long Tailed Tits and Black Cap I saw last > week, whilst others, like Blackbirds, insist on > bathing alone and will chase away other birds that > try and hop in alongside. Well, the blackbirds are rather larger than the others!

DulwichDaddio Wrote: ------------------------------------------------------- > If this is an example of good news, then the OP > must lead a really, really boring life. Ah, a "new" poster, just joined under this name today. How lovely. Wonder how long it will be before this incarnation gets banned?

?9.95?! You should have taken it back and complained. They would have refunded you. I doubt there is much crossover between M&S customers and Co-op customers. Once M&S opened, I rarely used the Co-op. Even though I fully support their ethic, apart from a few things, M&S just seemed better value, and was actually cheaper than I had expected. ETA: However, once I can, I will definitely check the new Co-op out. But they had always seemed to have supply problems, or management problems, or both, particularly in the fruit and veg section. ETA: I think M&S generally have problems, though less so with the food side. They have major problems on the clothing side, for various reasons, and now they are closing their bank. Which is very annoying as I have a current account with them (luckily not my main account) and now I've got to move it elsewhere. Though at least it's much easier to do that these days. Sorry admin, way off topic, stream of consciousness, as you were, back to the Co-op 🙂

I find pigeon behaviour fascinating. A pair of wood pigeons come to feed at the ground feeder in my garden. The male (I presume. Large and bossy 🤣) takes over the feeder, wolfing down seed. Whenever the female (I presume. Smaller and timid). gets anywhere near it, she is chased away. She is left to scavenge for seed in other parts of the garden nearby. No wonder he is so fat and she is so thin! (I have now started putting another pile of seed on the ground a little way from the first one, but it isn't in a feeder). However sometimes another male wood pigeon comes down and then the two males have a fight to see which gets to stay. Also interestingly, all the sparrows seem to come down for their first feed of the day around the same time as the pigeons. Weird. I don't put the seed out at a certain time each day, so it isn't that!

lameduck Wrote: ------------------------------------------------------- > Maybe they could reduce compost price for > subscribers of > garden waste > After all we are paying for them to take it > they may make more money That's a good idea!

Cora Wrote: ------------------------------------------------------- > But they've taken the great self service tills > out....the ones that don't beep every 2 minutes as > you try to balance your shopping.... Are there still self service tills? It always seemed a very strange arrangement of tills after the last refit, which I think was when they introduced them. I'm longing to have a look, but along with many others can't go shopping at the moment 😭 Anybody got any photos?!

The thing is, like the terrible dangerous (for pedestrians) junction where the South Circular meets the continuation of Lordship Lane by the derelict pub, if someone was killed or seriously injured here, they would come up with a solution PDQ. Speaking of which, I thought it had been agreed to install pedestrian crossings at the South Circular junction. Does anybody have an update on that? I can't remember what the timescale was.